Phillies vs Padres Series Odds: Unlikely Matchup Set in National League Championship Series
Veteran Pitchers Try to Lead Padres to First World Series Appearance Since 1998

Not a Division Champion to Be Found in National League Championship Series!
Considering all the moves that the San Diego Padres made to bolster the roster in the last couple of years, it might be hard to paint them in an underdog role. However, when you eliminate a Los Angeles Dodgers team that won 111 games during the regular season and dominated the Padres during the regular season, perhaps that tag does fit. Coming off that emotional win, the Phillies vs Padres series odds have this matchup nearly dead even.
None of the three division champions made it to the National League Championship Series. The Padres are going after the franchise’s first World Series title and first trip to the World Series since 1998 while the Philadelphia Phillies haven’t been to the World Series since 2009.
The series price list the Phillies at -105 and the Padres at -125 to win the National League title.
Phillies vs Padres Series Odds Information
Matchup: Phillies 87-75 (3rd, NL East) Padres 89-73 (2nd, NL West)
Date, time:
Streaming: Live Stream Sports
Probable Starting Pitchers
Tuesday: Philadelphia – TBA; San Diego – Yu Darvish
Harper Tries to Lead the Phillies to the Promised Land
With a Rookie of the Year award and two MVPs, Bryce Harper has done just about everything during his baseball career – with one exception.
Harper is looking to be a part of his first World Series championship team. His former Washington National teammates won it all the year that Harper headed to Philadelphia. His presence is a key in the Phillies vs Padres series odds.
Despite injuries that slowed him and limited him to being a designated hitter for much of the season, Harper helped Philadelphia make a late surge to reach the playoffs. When looking at the Philadelphia Phillies stats, he leads the Phillies with three home runs, six home runs and 22 total bases in the postseason. He’ll need to continue to produce against the Padres.
Grisham Delivering for the Padres
It has been a different story in the postseason with a .381 average to go with a team-high three home runs. It is quite a change from his last playoff experience when he was 3 for 22 with 11 strikeouts in 2020.
Few San Diego players struggled as much as outfielder Trent Grisham.
Grisham, in his third season with the Padres, batted just .184 with 11 fewer extra-base hits than he had last season.
It has been a different story in the postseason with a .381 average to go with a team-high three home runs.
It is quite a change from his last playoff experience when he was 3 for 22 with 11 strikeouts in 2020.
Grisham has reached base in all seven postseason games in 2022 as he is helping to provide some production from the bottom of the San Diego lineup. With all the stars at the top of the batting order, if Grisham continues to come through, that could play a role in the Phillies vs Padres betting odds.
Who’s Hot
- Jake Cronenworth, Padres 2B: Cronenworth was 7 for 16 with five RBIs over his last four games.
- Aaron Nola, Phillies P: Nola has allowed nine hits and no runs in 12.2 innings in his two postseason starts.
- Jean Segura, Phillies 2B: Segura was 6 for 13 with three runs, two doubles and two walks in the four games against Atlanta in the NL Division Series.
- Robert Suarez, Padres P: Suarez has allowed three hits and no runs with five strikeouts in six innings of work in the playoffs.
Who’s Not
- Mike Clevinger, Padres P: Clevinger allowed six hits and four runs in 2.2 innings in his lone playoff appearance in 2022.
- Brandon Drury, Padres 1B: Drury has one hit in 15 at-bats with six strikeouts during the playoffs.
- Zach Eflin, Phillies P: Eflin has allowed seven hits and four runs in 4.1 innings in four postseason appearances.
- Bryson Stott, Phillies SS: Stott is 2 for 15 with one extra-base hit in the postseason.
Phillies vs Padres Head to Head
The Phillies won three of the last four games and took the season series 4-3. There was just one game decided by one run while the road team won five of the seven matchups. The Padres won the three-game series in May played on the road, while the Phillies answered back by capturing three of the four contests at Petco Park in June.
Kyle Schwarber led the Phillies with seven RBIs and is tied with J.T. Realmuto with two home runs against the Padres during the regular season. Phillies starters Zack Wheeler, Aaron Nola and Ranger Suarez were 2-1 with an ERA of 1.27 against San Diego.
The only home run hit by a Padres batter this season against the Phillies was by Eric Hosmer and he finished the year playing for the Boston Red Sox. Catcher Austin Nola led San Diego with four RBIs against the Phillies.
Yu Darvish, slated to start the series opener, was 1-0 with a 2.08 ERA in two starts against the Phillies this season.
Phillies vs Padres Injury Update
For the Phillies, pitchers Corey Knebel (side) and Damon Jones (shoulder) are on the injured list.
The Padres played the entire season without shortstop Fernando Tatis Jr. (wrist) while pitchers Austin Adams (forearm) and Craig Stammen (shoulder) also had long-term injuries.
Phillies vs Padres Betting Preview
This is certainly not the matchup that people were expecting in the National League Championship Series. When looking at the MLB standings 2022, it is not often that two teams with less than 90 wins meet with a spot in the World Series on the line. What are the NL championship series odds?
The Padres were in playoff position for most of the season even if they failed to challenge the Dodgers for the NL West title as was the expectation coming into the season. At the All-Star break, the Phillies had the seventh-best record in the National League.
The key could be what happens when the teams go deep into the rotation.
San Diego’s Yu Darvish, Blake Snell and Joe Musgrove are a combined 4-0 in the postseason. For the Phillies, Aaron Nola is 2-0 and hasn’t allowed a run in 12.2 innings. Zack Wheeler is 0-1 despite an ERA of 2.19.
Philadelphia is more reliant on the home run than San Diego so keep an eye on how the runs are being scored and which team is able to sustain rallies.
The total has gone over in eight of Philadelphia’s last 12 games as well as in the last seven contests against NL West teams. The total has gone over in eight of the last 10 games for the Padres.
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