Bills vs Chiefs Lead Late Sunday: NFL Week 6 Odds and Spreads

The Much-Anticipated Rematch Headlines Triple-Header


Previewing NFL Week 6’s Late Sunday Afternoon

It’s six weeks into the 2022 NFL season. But for Josh Allen and the Buffalo Bills, it’s 38 weeks since their unfinished classic against Patrick Mahomes and the Kansas City Chiefs. The Bills now enter this Sunday as the three-point favorites via the NFL Week 6 odds and spreads even though the Chiefs just beat them. But the Bills would like to think they just “ran out of time” as Vince Lombardi put it. These rivals lead the late afternoon slate this Sunday beginning at 4:05 p.m. ET.

Buffalo Bills vs Kansas City Chiefs

  • Records: Bills (4-1), Chiefs (4-1)
  • Location: GEHA Field at Arrowhead Stadium, Kansas City, Kansas
  • Streaming: Live Stream Sports

Bills Raring to Run Chiefs Over

No one will complain if we have a Bills-Chiefs game at least once every regular season. These teams have combined for some magical games namely because of their quarterbacks: Allen vs Mahomes. The total has gone over in their last three meetings hence why it’s set at a whopping 54 points, the most for Week 6.

Allen blew Mahomes and the Chiefs out in their regular-season game last year. Then Mahomes and the Chiefs engineered an improbable comeback in the dying seconds of the Divisional Round to stun Buffalo in overtime. Allen and the Bills’ offense did not even get to see the field, which prompted the NFL to change the overtime rules.

This time around, Buffalo has plenty of momentum heading to Arrowhead. The Bills lead the NFL in point-differential (+91) and have an offense that scores the second-most points (30.4) and a defense that allows the fewest points. (12.2). And the Bills are doing it playing the likes of the Rams, Titans, and Ravens.

As for the Chiefs, they are also 4-1 like the Bills and have the best offense in the NFL (31.8 points per game) despite missing Tyreek Hill. However, Kansas City’s defense has struggled. This unit is 23rd in points allowed while opposing quarterbacks average a 105.5 passer rating against it. The Chiefs are 3-1 on both the moneyline and spread against the Bills. But if it can’t get its defense going, Buffalo will exact its revenge.

Arizona Cardinals vs Seattle Seahawks

  • Records: Cardinals (2-3), Seahawks (2-3)
  • Location: Lumen Field, Seattle, Washington

Birds Looking to Bounce Back

These NFC West teams are struggling on the NFL standings Week 6 but are still entertaining. Arizona has been reliant on its star quarterback Kyler Murray. Don’t let his stats fool you as Arizona’s two wins have been because of him. He’s put-together two game-winning drives and a fourth-quarter comeback already.

The 32-year-old is looking like Russell Wilson out there as he is completing a whopping 75.2 percent of his attempts and leads the NFL with a 113.2 passer rating.

And on the other end is Geno Smith. The 32-year-old is looking like Russell Wilson out there as he is completing a whopping 75.2 percent of his attempts and leads the NFL with a 113.2 passer rating. To think, he’s also done it against top-tier defenses like Denver, San Francisco, and supposedly New Orleans.

However, these teams are only 2-3 because their defenses aren’t that great. Specifically, with Seattle, the Seahawks can’t stop anyone – the team has allowed its last four opponents to score 27 or more points. It allowed 84 points in its last two games alone – that’s more than what six NFL teams have allowed for the entire season.

As such, the NFL week 6 odds and spreads favor Arizona. But the total, set at 50.5, could go over just as six of Seattle’s last seven games against its conference have.

Carolina Panthers vs Los Angeles Rams

  • Records: Panthers (1-4), Rams (2-3)
  • Location: SoFi Stadium, Inglewood, California

Beat-Up Rams Try to Beat Up Clawless Panthers

The Cardinals and Seahawks are not the only NFC West teams struggling. The Rams are having quite a trying year. The defending Super Bowl Champions are 2-3 and 1-4 against the spread (ATS). Partly to blame are this team’s prolific NFL injury report, namely quarterback Matthew Stafford. That elbow injury has sapped a lot of his prowess as he’s thrown just five touchdowns against a league-leading seven picks.

On the defensive end, the Rams are also not as dominant. This unit got lit up by the Bills in Week 1, let Atlanta score 17 fourth-quarter points, and then gashed by Dallas for 163 rushing yards. Most notably, the Rams have not forced a turnover in its last three weeks. So it speaks a lot on how bad Carolina is that the Rams are the biggest favorites for the NFL week 6 odds and spreads.

The Panthers will enter the game without its starting quarterback, Baker Mayfield while having the fewest yards. Even with the coaching change, third-stringer P.J. Walker may have a rough time trying to command the offense. The former XFL star has thrown two touchdowns versus eight interceptions in his brief NFL career.

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