Chargers vs 49ers Matchup Odds & Pick

The Chargers Have Failed to Cover 10 of Their Last 12 Games in November

Our Sunday Night Football prediction will come down to the running game. An aspect of the offense that neither team has excelled at this NFL season. Both squads are in a similar situation. The Chargers and the Niners are both in second place. Los Angeles trails the Kansas City Chiefs by one game in the football standings, but with a Chiefs head-to-head win under their belts, the Chargers are essentially two games behind in the AFC West. The Niners trail the Seattle Seahawks by 1 ½ games in the NFC west.

Game Information

Los Angeles Chargers (5-3) vs. San Francisco 49ers (4-4)

Date, time (TV):
Location: Levi’s Stadium, Santa Clara, California
Streaming: NBC


Chargers Defense Will be Ready for 49ers Threats

We’ve seen this many times over the years. On paper, the 49ers’ offense looks like it should be exciting but still has yet to live up to the hype. That caused the Niners front office to go out and pick up Christian McCaffrey, who saw more of a role in the offense in his second game.

This week San Francisco hopes to have Deebo Samuel back after not playing last week after suffering a hamstring injury. L.A.’s defense has allowed almost 26 points a football game, good for 30th in the league. So this looks like an easy San Francisco cover or perhaps an over, but as we continue our Chargers vs 49ers matchup odds preview we’ll learn that sometimes betting experience takes precedence over what looks to be an easy winner.

Los Angeles Threats are Minimal

NFL Injuries are not a good thing for a starting quarterback like Justin Herbert who will be without receivers Keenan Allen and Mike Williams, but it can be good for bettors who are looking to get an edge. Too often the betting public will look to a side if there are major injuries on the other, but we think it’s the total that should take priority in these situations.

We expect all those things to happen, and so does the public who has brought the send-out total of 47.5 to 45.5.

A lack of reliable weapons means that we should see underneath routes, check downs to the running back, and an emphasis on establishing the ground attack. We expect all those things to happen, and so does the public who has brought the send-out total of 47.5 to 45.5.

That’s right about the edge of where we want to be with the total. History tells us that even though the Chargers allowed over 200 yards rushing to the Atlanta Falcons before their bye week, it’s safe to say that stopping the run was a point of emphasis for head coach Brandon Staley, but that won’t stop Niners Head Coach Kyle Shanahan from testing the waters. All in all, it feels like a game that will be won at the line of scrimmage.

Public Taking the Touchdown and Under

We’re not sure where all the public confidence is coming from, but 61% of the tickets written on this clash are coming in on the Chargers. The early number was crushed by the wise guys, taking the opening number of -4 and driving it up to the magic number of -7. On Wednesday, we finally started to get small public money, but it hasn’t been enough to get off what looks to be a solid -7.

This can’t be a case of the ‘Joe’s’ thinking the Chargers have an advantage with their injuries. It’s more likely that it’s just a matter of the bettor seeing a touchdown and blindly grabbing it.

To conclude our Chargers vs 49ers matchup odds preview, our official recommendation is to play the under, but get it quick because this number has already fallen to an uncomfortable level.

Chargers vs 49ers Matchup Odds

Last Updated: 11/11/2022Team
Moneyline49ers -300, Chargers +245
Spread49ers -7
Total45.5
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