Super Bowl Path: San Francisco 49ers Future Betting Odds
The Trey Lance Era is About to Get Underway in San Francisco

San Francisco Top Contender in Stacked NFC West
San Francisco won 10 games during the regular season and came three points away from reaching the Super Bowl for the second time in the last three years. Now the 49ers have a chance to post back-to-back 10-win seasons for the first time in nearly a decade. Let’s take a look at the San Francisco 49ers future betting odds.
Last year rookie running back Eli Mitchell emerged into a starring role and this year, it could be quarterback Trey Lance’s turn to shine. With Nick Bosa and Fred Warner among the returnees on a defense that was third in the NFL in yards allowed a season ago, the offense won’t need to do that much to help the 49ers return to the playoffs.
Take a look at the PointSpreads page, and keep updated with the NFL news, and many more player totals in our San Francisco 49ers stats.
One major headache was averted when San Francisco signed unhappy receiver Deebo Samuel to a lucrative extension. Having Samuel build on a brilliant 2021 season should help quarterback Trey Lance make the transition from a high draft pick to starting quarterback. Keeping tight end George Kittle healthy will be a huge help for Lance as well.
It will be interesting to see what San Francisco does with former starting quarterback Jimmy Garoppolo who is coming off a season with 3810 passing yards. How will this change the San Francisco 49ers future betting odds, if at all?
Lance Ready to Take Over as Unquestioned Starting QB
Trey Lance

- Passing Yards: 3450.5
- Touchdowns: 21.5
- Interceptions: 11
The 49ers didn’t give up three first-round picks so they could move up to draft Trey Lance with the third overall selection in last year’s draft so he could sit on the bench. He will be running the offense in 2022 and with playmakers at all the skill positions, he could be ready to emerge into one of the top passers in the NFL.
Lance only played in six games as a rookie when he completed 57.7% of his passes for 603 yards with five touchdown passes and two interceptions.
San Francisco has used top-100 picks to select three running backs, three receivers, and two offensive linemen in the last five drafts and that could lead to San Francisco improving from a team that was 13th in scoring offense a season ago.
Mitchell Leads the Way in Crowded Backfield
The San Francisco 49ers certainly love drafting running backs. Even with the return of Eli Mitchell, Jeff Wilson, and Trey Sermon, the 49ers selected Tyrion Davis-Price in the third round of April’s draft.
Trey Sermon and Jeff Wilson were limited to nine games each a season ago so it will be worth watching how the carries are allotted with a full group of talented running backs to work with.
Is Mitchell the Next Great San Francisco Running Back?
Elijah Mitchell

- Rushing Yards: 925.5
- Rushing Touchdowns: 6.5 (-130o)
With the way Mitchell thrived as a rookie, he would seem destined to become a 1,000-yard rusher sooner rather than later. Mitchell had the first 100-yard games as a rookie and almost added another one with 96 yards in a win over Dallas in San Francisco’s playoff opener.
With the threat of Lance running with the ball in the red zone, Mitchell could see his touchdown total impact with more of a rushing threat starting at quarterback. The emergence of Mitchell, who was the 10th running back selected in the 2021 NFL Draft, is a reason why that position is often undervalued during the draft process.
Brandon Aiyuk

- Receptions: 58.5
- Rushing Yards: 775.5
- Rushing Touchdowns: 4½ (-140o) Â
It can be easy to forget about Aiyuk who is overshadowed by the dynamic of player Deebo Samuel. Aiyuk had 10 catches for 203 yards in the final two games of the regular season to remind people why San Francisco selected him in the first round of the 2020 NFL Draft.
With Samuel and tight end George Kittle likely drawing most of the attention from opposing defenses, there could be chances for Aiyuk to break out during the 2022 season. The goal will be for Aiyuk to come down with more catches after having 66 receptions on 84 targets during the 2021 regular season.
What Does Samuel do for An Encore?
Deebo Samuel

- Receptions: 70.5
- Receiving Yards: 950.5
- Receiving Touchdowns: 6.5 (even odds to go over)
Samuel took the NFL by storm a season ago. Not only did he have 77 catches for 1405 yards and six touchdowns, but he was also San Francisco’s second-leading rusher with 365 yards.
The sense is that his rushing attempts could drop significantly. It will also be worth monitoring to see if Samuel has the same chemistry with Lance at quarterback that he did when Jimmy Garoppolo was throwing him the ball.
Samuel kicked off the 2021 season with 189 yards on nine catches. He was targeted at least eight times in each of the first eight games of the season. It seems likely that he might not see the ball quite as much in 2022. However, he should remain one of the best pass catchers in the NFL
George Kittle

- Receptions: 66.5
- Receiving Yards: 825.5
- Receiving Touchdowns: 5.5
With 13 games missed during the last three regular seasons, the key for Kittle is to remain healthy. When is on the field, Kittle is one of the best tight ends in football. He had back-to-back 1,000-yard seasons in 2018 and 2019 and was on pace to hit that mark again in 2020 before injuries slowed him down.
With the continued development of Samuel and Aiyuk, it is possible that San Francisco won’t need to involve Kittle in the offense as much as it did earlier in his career. That could be a reason for the lower expectations for receptions and receiving yards in 2022. Plenty of young quarterbacks have relied on the pass-catching skills of tight ends and it won’t be a surprise to see Lance go that route early in the season. There you have it, the San Francisco 49ers future betting odds, be sure to follow us all year long for the best and most recent odds.
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