The Biggest NFL Week 7 Underdogs: Fade or Favor These Wanting Squads?
Can We Expect Big Upsets Just Like Week 6?

More Wide Lines in Buffalo and San Francisco Games
Last week, two of the three largest underdogs came away with wins on the betting lines. The Giants and Browns covered their spreads with the latter even winning outright. Buffalo and San Francisco were on the losing side as wide favorites. Now, they’re back as they take on two of the biggest NFL Week 7 underdogs. It could be dogs beating the spreads again, though are they worth betting?
Can Vikings Plunder San Francisco?
- Opponent: vs San Francisco 49ers
- Point Spread: Minnesota Vikings +7 (-115)
- Moneyline: +250
What are the odds of San Francisco taking another “L”? Kyle Shanahan’s 49ers have not lost consecutive games since Week 7 of the 2021 season. And the Vikings do not match up as well as the Browns did. Minnesota has a porous defense, a nonexistent running game, and now is without superstar receiver Justin Jefferson.
Cousins’ NFL stats declined sharply without him. He managed just 181 passing yards and a touchdown versus the Bears’ 29th-ranked scoring defense. The 49ers limited opposing quarterbacks to a 67.2 passer rating this season. Minnesota will be hard-pressed to do anything to San Francisco. It is just 3-8-1 against the NFL point spread (ATS) in its last 12 games and is 0-6 ATS in its last six home games. Unlike last week, San Fran runs away with this game.
Pick: San Francisco 49ers -7 (-105)
Will Cardinals Be Easy Prey for Seahawks?
- Opponent: vs Seattle Seahawks
- Point Spread: Arizona Cardinals +8 (-115)
- Moneyline: +280
Arizona’s feel-good season lasted all but three weeks. Since upsetting Dallas in Week 3, the Cardinals have not won a game or beaten a spread. It has been outscored an average of 16.7 points in its losses. Now, it visits the Seahawks, whose defense has played well for consecutive weeks. Folks are betting the ‘under’ on the total in this game for a reason (now at 44.5 from 45.5).
Regarding NFL Week 7 underdogs, we don’t like Arizona’s chances. The Seahawks offense is due for a big game after managing just 37 total points in their last two games. Seattle is just 0-5 ATS in its last five division games. But Arizona tops that: 1-10 ATS in its last 11 division games. It’s hard to put much faith in this team as it’s starting to be as bad as the preseason predictions.
However, the line has now gone to where it’s better to back to Arizona. Eight points is significant, and there is a good chance Arizona hits a late touchdown to get a backdoor cover. Either bet the spread or just pass.
Pick: Arizona Cardinals +8 (-115)
Not a Patriots’ Day on Sunday with These Odds
- Opponent: vs Buffalo Bills
- Point Spread: New England Patriots +9 (-120)
- Moneyline: +335
For the second straight time on the NFL football schedule, the Bills are the largest favorites. They failed to cover against the Giants but now have a more manageable spread of “only” nine points. That still means Buffalo needs to win by a touchdown and a field goal. Fortunately, the Bills are 4-1 ATS in their last five trips to Foxborough. And the Patriots are just as bad, if not worse, than the Giants on offense.
The Patriots are scoring just 12 points per game, which is second-worst in the NFL. They are also last in average points scored per drive. Mac Jones has thrown seven interceptions against five touchdowns. He has no good receivers, a declining offensive line, and a running game that averages 3.4 yards per carry. Now he has to contend with the Bills’ defense, which leads the league in sacks (24) and pressure rate (31.1%).
Buffalo has not blown out an opponent in two weeks. This will finally be that week as it clobbers this poor NFL Week 7 underdog.
For NFL betting news, odds analysis, and more, visit Point Spreads Sports Magazine.
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