Bills vs Rams Betting Odds: A Super Bowl-Sized Season Opener

Super Bowl Favorites Take on The Super Bowl Champs

The NFL kick-off 2022 opens with a heavyweight showdown between the Buffalo Bills and the Los Angeles Rams. Here you have the Super Bowl favorites, the Bills, taking on the defending Super Bowl Champions, the Rams. The Bills vs Rams betting odds have Buffalo, the visitors, as three-point favorites. But this one opened at a pick’em with plenty of storylines to navigate.

Bills vs. Rams Game Info

  • Game: Buffalo Bills (11-6-0, 2021) vs Los Angeles Rams (12-5-0, 2021)
  • Location: SoFi Stadium, Los Angeles, California
  • Day/Time:
  • Live Stream: NBC, Peacock

Bills Got Even Better on Paper

The Bills went down swinging in the Divisional Playoffs but are ahead of the likes of the past Super Bowl winners in Kansas City (the team they lost to), Tampa Bay, and the Rams. That’s likely because all these teams lost plenty of key players and personnel while the Bills added stars. Notably, Buffalo bolstered both of their lines.

The team added Titans teammates David Quessenberry and Rodger Saffold as they look to improve both the pass protection and running game. On the defensive end, they reacquired 2016 first-round pick, Shaq Lawson and Von Miller. The latter is the same two-time Super Bowl winner who had a renaissance late last year.

Josh Allen should continue to grow as a quarterback and a leader for the team. He’ll now also have James Cook as a new weapon at running back while Jamison Crowder will replace Cole Beasley as the slot receiver. The team should pick up where it left off as the Bills vs Rams betting odds attest.

Rams Have Several Key Figures Missing

The Super Bowl Champions may not only suffer from a “Super Bowl hangover” but from some injuries as well. Star quarterback Matthew Stafford has a lingering elbow injury that could impede his performance. Van Jefferson is also banged up and running back Cam Akers may still not be fully healthy. Los Angeles also lost a handful of important players.

Robert Woods and Odell Beckham Jr. have left the team from the receiver room along with starting linemen Andrew Whitworth and Austin Corbett. Miller is missing from the team’s pass rush and Sebastian Joseph-Day will also be missed from the front seven.  On top of that, the team lost almost all of its offensive coaching staff from offensive coordinator Kevin O’Connell to offensive assistant Chris O’Hara.

Factoring all this in leads to the Rams as an underdog on their own turf per the Bills vs Rams betting odds. But we can never underestimate a champion. The last four Super Bowl Champions have all won their NFL season starts. The Rams remain one of the most talented teams even with their losses. They also added Bobby Wagner and Allen Robinson to make up for some of their departures so this team remains elite.

Von Miller: Is There a “Revenge” Factor at Play Here?

The spotlight will be on the team’s quarterbacks and on one Von Miller. The eight-time Pro Bowler will face his old team and even if there seems to be no ill will on either side, Miller could be extra motivated. The 33-year-old inked a massive six-year deal with the Bills but he could just make the Rams regret not bringing him back at Stafford’s expense.

Miller started off 2021 on a strong note as he racked up a pair of sacks against the Giants. He also finished the year with 2.0 sacks in the Super Bowl as he totaled 4.0 sacks in four playoff games.  Given that he’s 33 with an injury history, Miller may not be the same explosive athlete he used to be. But he still has the veteran savvy and the familiarity with his old team to be a menace when the NFL kicks off this 2022.

Bills-Rams Betting Trends

The Bills are 4-1 against the spread (ATS) in their last five games against the Rams. Buffalo was favored in all five games.

Stafford is 0-2 in his career against Buffalo. He averaged 219.5 passing yards with a 66.7 completion rate and a 92.3 passer rating. Allen is 1-0 against the Rams in a game where he tossed four touchdowns while completing 72.7 percent of his pass attempts.

The total has gone over in four of Buffalo’s last five road games. Contrarily, the total has gone under in six of the Rams’ last seven home games.

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