The Carolina Panthers lead the series going into this season, although the two teams have not met since an October washout at Levi’s stadium. On that day, the 9’ers walked away with a big win after Tevin Coleman and Raheem Mostert ran riot in the running game. The visiting team has struggled to assert dominance on previous visits to Carolina, winning only 1 of their last 4 attempts.

Expect this Panthers team to come out fighting after a disappointing 5-12 finish last year with only 2 wins posted for their home fanbase. It is likely to be a battle that’s won on defense, with both teams having top three finishes in the regular season for yards lost per game. Unfortunately for the Panthers, offensive yards proved more of a challenge, with only the Giants and the Texans recording less output through the 2021 season.

Now that you’re aware of the facts for 49’ers vs Panthers, all that remains to be done is to wait for the big confrontation and see who comes out on top. We advise backing the 49’ers on the road this week if you intend to bet on NFL games, although we should be expecting a tightly contested affair. The 49’ers will surely be looking to recreate the blowout of last year at Levi’s stadium, although they didn’t have as much luck on the reverse trip to this stadium.

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