Home » NFL » Matchups » Detroit Lions vs San Francisco 49ers Detroit Lions 49ersView current matchupPrevious Matchups January 28, 202428/01/20241.30 PM ESTLevi's Stadium September 12, 202112/09/20218.00 AM ESTFord Field September 16, 201816/09/201811.05 AM ESTLevi's Stadium December 27, 201527/12/20158.00 AM ESTFord Field September 16, 201216/09/20123.20 PM ESTCandlestick Park October 16, 201116/10/20118.00 AM ESTFord Field December 27, 200927/12/200911.05 AM ESTCandlestick Park September 21, 200821/09/200811.05 AM ESTCandlestick ParkView current matchupDetroit Lions vs 49ers Betting Odds WIN PROBABILITY PREDICTED SCORE BETTING TRENDS SPORTS TRENDS RETURN ON INVESTMENTLAST 10 GAMES Detroit Lions 49ers RECORDS​ HEAD TO HEAD TEAM RANKED STATSREGULAR SEASON Detroit Lions 49ers TEAM LEADERS Detroit Lions 49ers INJURIES Detroit Lions 49ers Detroit LionsVISIT TEAM PAGE49ersVISIT TEAM PAGELATEST NFL NEWS 2024 NFL Week 1 Odds: Anticipating An Amazing Rookie Class! 2024 NFL QB Starters Odds: Which QBs Get Passing Grades? Jets, Texans to Get Prime Exposure on NFL Schedule NFL Defensive ROTY Odds: Turner the Early Favorite A Bear Market? QB Williams The Rookie of the Year Front-Runner 2025 NFL Draft Early Odds: QBs Lead Best Bets 2024 NFL Draft Picks: Surprises! NFL Stunner: Falcons Choose Penix Jr Leaving Kirk Cousins in Shock! NFL Draft Recap: Atlanta Makes Shocking Top-10 Pick A Pair Of Receivers Could Sneak Into First RoundDetroit Lions vs 49ers Highlights​