NFL Full Schedule Week 15 Odds: Plenty of Close Games Expected
Cowboys at Buffalo Top Game of the Week

The NFL Week 15 schedule isn’t the most compelling, although there are a few pretty good match-ups on the slate. But what is a good game for fans doesn’t always translate into a good game for sports bettors and vice versa.
There are quite a few toss-up games, with the NFL full schedule Week 15 odds showing nine games with point spreads of 2.5 or fewer points. Here is the NFL Week 15 Full Schedule with spreads.
Los Angeles Chargers at Las Vegas Raiders 
Day/Time:
Odds: Los Angeles -2.5
Moneyline: Los Angeles -130
The week begins with an AFC West matchup between the Chargers and the Raiders. This is the second time the teams have met this season. The teams split their two games last season. Las Vegas went 4-4 at home last season, while the Chargers were 5-5 on the road including the playoffs. Los Angeles was 6-3-1 ATS on the road, going 3-2-1 ATS as an away favorite and 5-1 straight-up. The NFL Week 15 lines suggest giving the Chargers a good look here.
Chicago Bears at Cleveland Browns 
Day/Time:
Odds: Cleveland -3.5
Moneyline: Cleveland -175
The NFL full schedule Week 15 odds look to be a little cheap on the Browns here if Deshaun Watson is playing the way Cleveland thinks he’s capable of. This is the second of two straight home games for Cleveland, who faced the Jaguars last week. Chicago is coming off three straight division games. The NFL Week 15 Vegas odds favor the Browns a little bit in this game.
Atlanta Falcons at Carolina Panthers 
Day/Time:
Odds: Carolina -1
Moneyline: Carolina -115
The Panthers are in a rare favorite role this game, one of four contests in Carolina that is the early favorite. Carolina was 0-4 straight-up and against the spread as a favorite last year. The Falcons were just 3-9 straight-up as an underdog last season and 7-5 against the point spread. But given Carolina’s inability to win as a favorite, Atlanta is a good team to take for your NFL Week 15 spread picks in a teaser at +7.
Denver Broncos at Detroit Lions 
Day/Time:
Odds: Detroit -2
Moneyline: Detroit -130
This one could turn out to be a pretty good game depending on how Russell Wilson is playing. With Detroit the early favorite to win the NFC North, these are the types of games the Lions have to win. Denver is coming off a big division game with the Chargers, while the Lions are returning home after two straight road games. The NFL Week 15 predictions point to the Lions laying less than a field goal in this spot.
Tampa Bay Buccaneers at Green Bay Packers 
Day/Time:
Odds: Green Bay -3.5
Moneyline: Green Bay -175
The NFL full schedule Week 15 odds have Green Bay laying 3.5 points to Tampa Bay Buccaneers. There are quarterback questions surrounding both teams, but the Packers appear to be in a better situation with Love. Tampa Bay’s defense will be under a lot of pressure all season long. This is the second straight road game for Tampa Bay. The Packers could have a tough time matching Detroit and Minnesota in the NFLÂ standings this season, but this is the type of game the Packers should win. The NFL Week 15 against the spread picks like Green Bay in this one.
Pittsburgh Steelers at Indianapolis Colts 
Day/Time:
Odds: Pittsburgh -2.5
Moneyline: Pittsburgh -130
The NFL full schedule Week 15 odds show Pittsburgh as a road favorite in this one against the Colts. Anthony Richardson should be playing better at this point in the season. How he plays will determine how the Colts fare this season. The Steelers have a key home game with the Bengals the following week. For Indianapolis, this is the only home game in a four-week stretch, so you should get a good effort from the Colts. The NFL Week 15 odds and predictions are really like Indianapolis in a teaser at +8.
New York Jets at Miami Dolphins 
Day/Time:
Odds: Miami -1.5
Moneyline: Miami -120
This is one of the better NFL Week 15 matchups on the schedule. The Jets should be totally focused on this one, coming off games with the Falcons and Texans and having Washington on tap. Miami does have the Cowboys up next. But there’s no excuse for Miami to be looking ahead when facing a division rival. The NFL odds are cheap on Miami in this one and the Dolphins offer decent value with such a low point spread.
New York Giants at New Orleans Saints 
Day/Time:
Odds: New Orleans -2.5
Moneyline: New Orleans -130
This one could turn out to be a decent game. New Orleans is the favorite in the NFC South, while New York will be looking to return to the playoffs as a wild card. This is the third straight home game for New Orleans and the Saints need to take advantage of that. The Giants have the Eagles up next, as they play Philadelphia twice in the final three weeks of the season. The NFL Week 15 line of New Orleans -2.5 should have you giving the Saints a good look, especially if the NFL scores show Derek Carr is fitting in with the team.
Minnesota Vikings at Cincinnati Bengals 
Day/Time:
Odds: Cincinnati -5
Moneyline: Cincinnati -220
This one could be trouble for the Bengals if they get caught looking ahead to next week’s game with the Steelers. The Vikings were just 2-4 straight-up and ATS as an underdog last year, but are capable of coming up with big efforts from time to time. The Vikings do have the Lions up next, but depending on their record, this could be a game they really need. The NFL Week 15 spreads favor Minnesota a little bit here.
Houston Texans at Tennessee Titans 
Day/Time:
Odds: Tennessee -3
Moneyline: Tennessee -150
The Titans are favored by 3 and the NFL Week 15 betting lines seem to be a little low on Tennessee in this one. The Texans are going to be better, but it could take some time. CJ Stroud has plenty of talent but is still a rookie. The Titans have plenty of veterans and they should still be ahead of Houston. This line suggests the Titans are just a point better than Houston and have to believe Tennessee is closer to three points better on a neutral field. Tennessee deserves some consideration as a play in this one.
Washington Commanders at Los Angeles Rams 
Day/Time:
Odds: Los Angeles -1
Moneyline: Los Angeles -115
The NFL full schedule Week 15 odds have the Rams in a rare favorite this season. Los Angeles is favored in just three games, although that could change once the season begins. The Rams could be a little better than expected depending on the NFL Week 15 injury report. Washington will battle, although they could be looking ahead to the Jets, 49ers, and Cowboys, which isn’t an easy three-game stretch to end your season. Right now, the Rams look to be the right side in this one.
San Francisco 49ers at Arizona Cardinals 
Day/Time:
Odds: San Francisco -6.5
Moneyline: San Francisco -265
The 49ers have the largest of the NFL Week 15 point spreads to cover, but this isn’t the best of spots for San Francisco. The 49ers are coming off the Eagles and Seahawks and have the Ravens up next. Getting motivated for a division opponent they should have beaten handily in Week 4 might be a bit of a problem. The Cardinals are going to struggle this year. The biggest question surrounding Arizona is if they sit Kyler Murray the entire year or not. If they get off to a slow start, as expected, the Cardinals could let Murray recover and use the high draft picks to get him some help for 2024.
Dallas Cowboys at Buffalo Bills 
Day/Time:
Odds: Buffalo -4
Moneyline: Buffalo -190
A big game here for both teams. The Cowboys just wrapped up a three-game home stand against the Eagles the previous week and now travel to Buffalo. Dallas was 3-3 as an underdog last season and 5-1 in teasers when underdogs. The Bills were 14-4 straight-up but just 7-11 ATS as a favorite last season. Buffalo was 3-1 ATS when favored by 4 or fewer points. All four games also went under the total. This is part of a brutal stretch for Buffalo, who just played the Jets, Eagles and Chiefs and have the Chargers on deck. The NFL Week 15 over under predictions like Buffalo’s under trend as a small favorite.
Philadelphia Eagles at Seattle Seahawks 
Day/Time:
Odds: Philadelphia -2
Moneyline: Philadelphia -125
This is a pretty decent game here and a good time for Seattle to catch Philadelphia. The Eagles are coming off a tough stretch where they played Dallas, Kansas City, Buffalo, San Francisco, and Dallas again. Nobody would blame the Eagles if they didn’t have much left in the tank after that five-game stretch. Not that Seattle has had it easy the last few weeks, either. Seattle had two games with San Francisco and a game with Dallas. This game will probably mean a little more to Seattle, which figures to have a tougher road to return to the playoffs. The NFL Week 15 odds and predictions suggest taking Seattle +8 in a teaser.
Baltimore Ravens at Jacksonville Jaguars 
Day/Time:
Odds: Jacksonville -1
Moneyline: Jacksonville -115
Another pretty good Sunday night game, especially if Jacksonville can take that next step forward. That’s pretty much the key to this game. The Ravens should be focused on this one, as they’re coming off a game with the Rams. The schedule will get tougher for Baltimore, beginning with this one, as San Francisco, Miami, and Pittsburgh are waiting in the wings. The Jaguars get another prime-time TV slot and are returning home after a game with Cleveland. This is one of the toughest games to try and guess the NFL Week 15 scores. If the Jaguars play as expected, this line is a little low. If Jacksonville reverts back to its previous form, the wrong team is favored.
Kansas City Chiefs at New England Patriots 
Day/Time:
Odds: Kansas City -4
Moneyline: Kansas City -185
Kansas City visits New England for the Monday night game and the Chiefs are coming off a showdown with Buffalo. There’s never a good time to be playing Kansas City, but if you have to face them, right after the Bills is probably as good of a time as any. The Patriots aren’t going to be as bad as their record, but New England has a brutal schedule.
In addition to six tough division games, the Patriots also face Philadelphia and Dallas, among others. Those taking the Patriots here may be betting more against Kansas City than on New England. The Chiefs might have a tougher time than expected here, but it’s still hard to see them losing outright. Kansas City has to be one of your NFL Week 15 picks straight up. But it’s tough to lay the four points with the Chiefs.
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