
The NFL Week 4 full schedule has several big games on tap, with Miami facing off with Buffalo in an AFC East showdown. Patrick Mahomes and the Chiefs visit Aaron Rodgers and the Jets in the Sunday night contest. It’s the final full week of NFL games for a bit, as the bye weeks begin in Week 5.
Detroit Lions at Green Bay Packers 
Day/Time:
Odds: Detroit -1.5
Moneyline: Detroit -120
The NFL Week 4 full schedule starts with an NFC Central showdown between Detroit and Green Bay. The odds for NFL Week 4 have the Lions as 1.5-point road favorites in this one. The Packers have only been a home underdog three times in the last five years, covering all three games. The Lions are just 1-4 as a road favorite since 2019, but this could be their best team since they last made the playoffs in 2016.
Atlanta Falcons at Jacksonville Jaguars 
Day/Time:
Odds: Jacksonville -4
Moneyline: Jacksonville -180
The Jaguars host Atlanta in a game where the line appears slightly on the low side. But Jacksonville has to show that it deserves to be a good-sized home favorite against weaker teams. The Jags haven’t done that yet. The NFL power ratings have Jacksonville 5.5 points better than Atlanta, so the Jaguars could be one of your NFL Week 4 picks.
Minnesota Vikings at Carolina Panthers 
Day/Time:
Odds: Minnesota -1.5
Moneyline: Minnesota -120
The Vikings find themselves a road favorite, which may not happen often this season. Most people have figured out Minnesota was one of the luckiest teams in recent memory last season. But, so many people are down on the Vikings that they may become slightly underrated in the early going. They’re not as good as they appeared to be last year. But they’re not a bad team by any means. The NFL Week 4 point spread is pretty much spot on in this game.
Cincinnati Bengals at Tennessee Titans 
Day/Time:
Odds: Cincinnati -4.5
Moneyline: Cincinnati -195
The Bengals are favored a little more than they were here last year in Week 12 when Cincinnati pulled out a 20-16 win as 1-point favorites. Cincinnati isn’t in a great spot here. Road favorites who were favored in each of the last two weeks at home are 19-24 (44.2%) against the spread since 2020. The Bengals are risky NFL Week 4 favorites this week.
Pittsburgh Steelers at Houston Texans 
Day/Time:
Odds: Pittsburgh -3.5
Moneyline: Pittsburgh -175
Pittsburgh travels to Houston to face the Texans and are 3.5-point road favorites. This is the biggest road favorite the Steelers have been since the 2020 season. The NFL Week 4 odds in this one are more of a reflection on the Texans than they are on the Steelers. This figures to be a long season for Houston.
Tampa Bay Buccaneers at New Orleans Saints 
Day/Time:
Odds: New Orleans -4
Moneyline: New Orleans -190
NFC South rivals Tampa Bay and New Orleans meet for the first time this season. This one is a revenge game for New Orleans, who dropped both games to Tampa Bay last season. The Saints aren’t going to be the only team looking to settle a score with the Buccaneers. But they do get an early shot at it. New Orleans returns home for this one after playing its last two games on the road. The Bucs will be coming off a Monday night game with the Eagles. The Saints aren’t a bad NFL week 4 pick.
Baltimore Ravens at Cleveland Browns 
Day/Time:
Odds: Cleveland -1
Moneyline: Cleveland -115
This one could turn out to be a decent game. But the oddsmakers may be giving a little too much respect to the Cleveland Browns in this spot. The teams have split the last two years. But the Ravens have dominated the series, going 20-6 since 2010. The Ravens could be one of your NFL Week 4 NFL picks in a teaser, pushing the line up to a touchdown.
Washington Commanders at Philadelphia Eagles 
Day/Time:
Odds: Philadelphia -7 (-120)
Moneyline: Philadelphia -330
The Philadelphia Eagles are solid favorites over NFC East rival Washington. The Commanders did beat the Eagles once last year and have won three of the previous six games between the two. Philadelphia is coming off a Monday night game at Tampa Bay and is on the road for the next two weeks. So the Eagles should be focused on this game. The NFL Week 4 Vegas odds have this game pegged right on.
Miami Dolphins at Buffalo Bills 
Day/Time:
Odds: Buffalo -3.5
Moneyline: Bills -175
This game is one of the better ones on the NFL regular season schedule this week, as Miami visits Buffalo for an AFC East showdown. The Bills won both games last year but failed to cover the point spread either time. The Dolphins played Buffalo tough but couldn’t make the plays when they needed. The NFL Week 4 betting odds on this game may seem slightly low. But both games were decided by three points last year. There’s no reason this one isn’t another game that comes down to the wire.
Denver Broncos at Chicago Bears 
Day/Time:
Odds: Denver -1.5
Moneyline: Denver -120
The Denver Broncos find themselves as small road favorites in this one. Denver was a road favorite three times in a dreadful 2022 season and lost all three games straight-up. The Broncos should be a better team this season than they were a year ago. The Bears don’t figure to be anything special this season, but it’s still hard to lay points on the road with Denver until it proves last season was a fluke. Regarding NFL Week 4 betting, this game may just be one to stay clear of.
Los Angeles Rams at Indianapolis Colts 
Day/Time:
Odds: Los Angeles -1
Moneyline: Los Angeles -115
The Los Angeles Rams would like to forget the NFL scores from last year and just get out on the field healthy. The Rams had one of the most significant single-season drop-offs in NFL history last season. If the team can get healthy, they should be better than they’re given credit for. The Colts are going through a bit of a rebuilding phase and wins figure to be hard to come by this season. As one of your NFL Week 4 experts picks, the Rams aren’t a bad choice.
Arizona Cardinals at SF 49ers 
Day/Time:
Odds: San Francisco -9.5
Moneyline: San Francisco -410
The 49ers are being asked to cover a pretty steep number in this divisional rivalry. San Francisco won both games between the two teams last year after losing twice to the Cardinals in 2021. The 49ers are coming off a home game with the Giants and host the Dallas Cowboys the following week. So even though Arizona is a divisional foe, it could be a bit of a flat spot for the 49ers. Arizona could be a decent selection as one of your NFL Week 4 parlay picks or teaser picks.
New England Patriots at Dallas Cowboys 
Day/Time:
Odds: Dallas -4.5
Moneyline: Dallas -2-5
The price is pretty reasonable on the Cowboys for this non-conference game against New England. The Cowboys do have the 49ers on deck, but it’s hard to look past a Bill Belichick-coached team. Still, the Cowboys could be guilty of peeking ahead a little bit. Dallas is still a little overpriced at home, going 17-17-1 as a home favorite over the last five seasons. This is one of the toughest NFL Week 4 point spreads to figure out.
Las Vegas Raiders at LA Chargers 
Day/Time:
Odds: Los Angeles -5.5
Moneyline: Los Angeles -215
The Raiders visit the Chargers in an AFC West tilt and the Chargers are decent-sized home favorites. Las Vegas and Los Angeles split their two games last season. The Raiders will be a different team this season with Jimmy Garoppolo playing quarterback. Las Vegas may not make as many big plays, but they shouldn’t make as many bad plays, either. How he’ll fit with a team that doesn’t have a great defense remains to be seen. This is one of the better spreads for NFL Week 4 and a tough game to predict.
Kansas City Chiefs at New York Jets 
Day/Time:
Odds: Kansas City -2
Moneyline: Kansas City -125
The NFL is getting maximum airtime for Rodgers and the Jets and you can’t blame them. A huge television market and one of the biggest names in the NFL joining forces is too good for the networks to pass up. Once again, the Jets are playing a tough foe. New York’s first four games are against the Bills, Cowboys, Patriots, and Chiefs. The Jets have the Broncos and Eagles up next, so it’s definitely one of the toughest schedules to open the season. The Chiefs have proven to be vulnerable on the road at times in the last few seasons. With New York’s defense, this could be one of your NFL Week 4 best bets by using the Jets in a teaser.
Seattle Seahawks at New York Giants 
Day/Time:
Odds: New York -1
Moneyline: New York -115
The NFL Week 4 full schedule winds up with the Monday night game between Seattle and the New York Giants. New York isn’t getting a lot of respect here, being just 1-point favorites at home. Both squads were playoff teams a year ago. The Giants weren’t quite as good as they looked and that’s a bit evident in the point spread for this game. Being the Monday night game, this one with be a popular NFL Week 4 parlay with people taking a side and the total. It should be an entertaining game, but it’s a tough one to call.
For NFL betting news, odds analysis, and more, visit Point Spreads Sports Magazine.
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